The effect of malnutrition on cardiac function in African Children. Archives of Dis Child on-line publication Nov 9th 2015

Silverman Cardiac function in severe malnutrition Arch Dis Child 2015

  • How did the investigators measure cardiac function?
  • What is the difference between cardiac output and cardiac index?
  • What were the main findings of the study?
  • What factors might influence cardiac index in malnutrition?



Prevention of mother-to-child transmission of HIV and the health-related Millennium Development Goals: time for a public health approach. Lancet 2011; 378:282-84

Shouten WJ PMTCT Option B Malawi Lancet 2011

  • What is Option B+?
  • Why did Malawi change to this option?
  • Prior to Option B+, what was the recommended CD4 count for starting ART in pregnant women?
  • In Option B+, what treatment is given to the baby, and for how long?
  • Are there any potential disadvantages of Option B+?



Interventions to improve adherence to treatment for paediatric tuberculosis in low- and middle-income countries: a systematic review and meta-analysis. Bull World Health Organ 2015;93:700-711

Weaver Adherance to Paediatric TB treatment Bull WHO 2015

  • What factors did the authors find promoted or threatened adherence to treatment for paediatric tuberculosis?
  • What interventions had the most success in promoting adherence?

Achieving high treatment success for multidrug resistant TB in Africa: initiation and scale up of MDR TB care in Ethiopia – an observational cohort study. Thorax 2015;70:1181-1188

 Meressa D MDR TB care in Ethiopia Thorax 2015.full

  • In Ethiopia what rate of treatment completion was achieved for MDR TB?
  • What drugs were used in the treatment, and what was the treatment duration?
  • What were the key elements of the follow-up program?  What adherence strategies were used?
  • What side effects were described from the MDR TB treatment?


Check your Answers here

December 2015 Paediatric Society CME Q&A