February

Germovsek E Aminoglycosides education and practice review ADC 2017

Rytter Immune system in children with malnutrition PLOS ONE 2014

D’Acremont V Multiple causes of fever in children’s outpatients in Tanzania NEJM 2014

The wide spectrum of causes of fever

Beyond malaria – causes of fever in outpatient Tanzanian children
D’Acremont V, et al N Eng J Med 2014; 370: 809-17

1. Describe the population of febrile children that were studied?
2. What were the proportions of viral, bacterial and parasitic disease?
3. What were the common causes of respiratory infection?
4. What was the commonest cause of systemic infections (systemic fever)?
5. What proportion of the children had malaria, and what percentage of the children with malaria had another condition?
6. How common was urinary tract infection?
7. How common was Human Herpes Virus 6 infection, and what clinical infection does this virus commonly cause?

Immune system in malnutrition

The immune system in children with malnutrition – A systematic review

Rytter MJH, et al. Public Library of Science (PLOS) ONE 2014; 9: Issue 8: e105017

1. What are the more common infections likely resulting fromsevere malnutrition?
2. The 3 different types of immunity include barrier function, innate and acquired immunity, what are the components of each of these?
3. What are the effects of severe malnutrition on barrier immunity?
4. What are the effects of severe malnutrition on innate immunity?
5. What are the effects of severe malnutrition on acquired immunity?

Aminoglycoside antibiotics

What do I need to know about aminoglycosides?

Germovsek E, et sl. Archives Diseases in Childhood Education Practice Edition 2017; 102:89-93

1. What infections can be treated by aminoglycosides?
2. How do aminoglycosides penetrate into a bacteria cell membrane?
3. How do aminoglycosides interrupt protein synthesis?
4. How are aminoglycosides distributed and excreted?
5. What is the toxicity of aminoglycosides, and what exacerbates them?

February 2018 CME Answers