Greenhill A Causes of meningitis in Goroka serotypes and resistance BMC Infect Dis 2016
Ali A Respiratory viruses in causing severe pneumonia in Karachi PLoS 2013
MENINGITIS
Streptococcus pneumoniae and Haemophilus influenzae in paediatric meningitis patients at Goroka General Hospital: serotype distribution and antimicrobial susceptibility in the pre-vaccine era.
Greenhill AR, et al BMC Infect Dis 2016; 15:485
- What population was studied?
- In what proportion of children with meningitis was a pathogen identified on CSF?
- How many serotypes of Streptococcus pneumoniae are included in the Pneumococcal Conjugate Vaccine, and how many serotypes exist?
- What proportion of pneumococcal isolates from CSF will be covered by the currently used PCV in PNG?
- What common serotypes are left out of the PCV that cause meningitis in PNG?
- What proportion of . Haemophilus influenzae during the 1996-2005 era were resistant to chloramphenicol?
- What proportion of S. pneumoniae isolates were resistant to penicillin?
VIRUSES CAUSING MODERATE AND SEVERE PNEUMONIA
Role of Human Metapneumovirus, Influenza A and Respiratory Syncytial Virus in causing WHO-defined severe pneumonia in children in a developing country
Asad Ali, et al. Public Library of Science (PLOS) 2013; 8:e74756
- What population was studied?
- How were respiratory viruses identified?
- What proportion of children with WHO-defined severe pneumonia (PNG classification of moderate or severe pneumonia) had respiratory viruses isolated?
- What were the proportions of children with severe pneumonia who had Human Metapneumovirus (HMPV), Influenza A and RSV
- What proportion of children with RSV had chest x-ray changes of pneumonia?
- What was the relationship of RSV and other viruses to weather and seasons?
- What are the limitations of this study, and what are the considerations in applying the study results in PNG?
- What are the implications for antibiotic prescribing?