January
TUBERCULOSIS
Treatment of tuberculosis. Horsburgh CR Jr, et al. New England Journal of Medicine 2015; 373:2149-2160
Horsburgh CR Tuberculosis treatment NEJM 2016.pdf PDF 1
- In the first 2 months treatment of TB, why is there a biphasic kill curve, and what are the implications of this for therapy?
- What other explanations are there for poor clinical responses?
- What is the current standard treatment regimen for drug-sensitive TB, and why is ethambutol added?
- What are the common drug toxicities?
- What is the recommended regimen for MDR tuberculosis?
CHIKUNGUNYA FEVER
Chikungunya virus and the global spread of a mosquito-borne disease. Weaver SC and Lecuit M. New England Journal of Medicine 2015; 373:1231-1239
Weaver SC Chikungunya virus global spread NEJM 2015.pdf PDF 2
- Where in the world did Chikungunya virus originate and what promotes its global spread?
- What are the clinical features of Chikungunya fever?
- Which children are most commonly affected?
- What are the long-term sequelae of Chikungunya fever?
- Are there any blood tests that can help diagnose Chikungunya?
- How can Chikungunya fever be prevented?
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