September – October 2018 CME Questions Causes of presumed neonatal sepsis and neonatal jaundice
Neonatal sepsis in Asia
Causes and incidence of community-acquired serious infections among young children in south Asia (ANISA): an observational cohort study Saha SK, et al. Lancet 2018; 392: 145–59
Saha et al Aetiology of Neonatal Infection in South Asia Lancet 2018
ANISA is a large study which enrolled 84,971 mothers antenatally in Bangladesh, India, and Pakistan, and used community health-care workers to follow up neonates after birth, and identify “neonatal sepsis”. It is an important study, because there are few population-based studies of community-acquired newborn sepsis in Asia.
- In the ANISA study what proportion of “neonatal sepsis” had a proven bacterial cause?
- What proportion of blood cultures were positive, and what were the common bacteria isolated?
- What proportion of “neonatal sepsis” was proven to be caused by viruses, and what was the most common virus isolated?
- Were standard treatment antibiotics effective?
- What is the main message of the study, regarding the causes of “presumed neonatal sepsis”?
Neonatal jaundice
Neonatal hyperbilirubinaemia: a global perspective
Olusanya, et al. Lancet Child Adolesc Health 2018 http://dx.doi.org/10.1016/S2352-4642(18)30139-1
Olusanya B Neonatal Jaundice Global perspective Lancet CAH 2018
A review of the epidemiology, causes, consequences and treatment of neonatal jaundice.
- What proportion of newborns become jaundiced, and what proportion have clinically significant jaundice?
- What level of bilirubin is visibly detectable?
- Is a little bit of jaundice good for newborn babies? Explain.
- What are the manifestations of bilirubin encephalopathy?
- What are the risk factors for severe jaundice in the newborn period?
- How does phototherapy work, and when should it be started?
- What are the indications for exchange transfusion, how does it work, and what are the complications?
- How can the complications of severe jaundice be prevented?
September – October 2018 CME Q&A Causes of presumed neonatal sepsis and neonatal jaundice